Hadasit Medical Research Services and Development Ltd.

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Abraham Rutenberg

Michal Lotem

Shoshana Frankenburg

Galit Eisenberg

Arthur Machlenkin

Ronny Uzana

Tamar Peretz-Yablonsky

Roni Engelstein

David Avnir

Vladimir V Vinogradov

The present invention is directed to the field of immunotherapy. Specifically, the invention provides compositions and methods for improved T cell modulation ex vivo and in vivo and for the treatment of cancer and other pathologies. More specifically, embodiments of the invention are directed to the use of soluble NTB-A polypeptides or agonists thereof for the treatment of cancer patients, for preventing and treating cytopenia in susceptible patients, and for the ex vivo preparation of improved cell compositions.

Methods for cancer therapy using isolated NTB-A ectodomain polypeptides

Provided is directed to the field of immunotherapy. Specifically, provided are compositions and methods for improved T cell modulation ex vivo and in vivo and for the treatment of cancer and other pathologies. More specifically, embodiments of the subject matter are directed to the use of soluble NTB-A polypeptides or agonists thereof for the treatment of cancer patients, for preventing and treating cytopenia in susceptible patients, and for the ex vivo preparation of improved cell compositions.

Cell compositions and methods for cancer therapy

Provided is a platform for entrapment within alumina sol-gel carriers of labile biologically active materials such as proteins, therapeutic enzymes, enzymes of industrial relevance, antigens, and small molecules for achieving successful and efficient protective storage, protection from harsh environmental conditions such as heat, pH and chemicals, delivery to site and subsequent treatment and/or vaccination against diseases against which the active agents are targeted.

Entrapment of bioactives in sol-gel alumina materials

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Haifa, Israel

Abraham Rutenberg