Cilag International Gmbh

Gatt Technologies Bv

Ethicon, Gmbh

Cilag Gmbh

Abraham Reinier Keereweer

Gerard H Llanos

Johannes Caspar Mathias Elizabeth Bender

Hubert Clemens Pellikaan

Joost Opsteen

Rosa Pilar Félix Lanao

Rosa Pilar FÉLIX Lanao

Biocompatible, flexible, haemostatic sheets are provided comprising a water-resistant cohesive fibrous carrier structure comprising a three-dimensional interconnected interstitial space and fibres comprising a nucleophilic polymer carrying reactive nucleophilic groups; and distributed within the interstitial space throughout the fibrous carrier structure, a plurality of reactive polymer particles comprising a water-soluble electrophilic polymer carrying at least three reactive electrophilic groups that are capable of reacting with both amine groups in tissue and blood and with the reactive nucleophilic groups of the nucleophilic polymer to form covalent bonds, wherein the reactive polymer particles have a diameter between 0.5-100 μm and are present in an amount of at least 3% by weight of the fibrous carrier structure.

Biocompatible, flexible, haemostatic sheet

The invention provides a method for preparing tissue-adhesive sheets that may suitably be applied as an implantable haemostatic or sealing construct during surgical procedures, said method comprising:

Method for preparing a tissue-adhesive sheet

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Nijmegen, Netherlands

Abraham Reinier Keereweer