Yeda Research and Develpment & Co. Ltd

Chi2gel Ltd.

The United States of America As Represented by the Department of Health

Chit2gel Ltd.

Abraham Patchornik

Abraham Nudelman

Fortuna Haviv

Rami Kalir

Zvi Nevo

Abraham Warshawsky

Dror Robinson

Yechiel Shai

Janina Altman

Noah Ben-Shalom

Shimeon Pass

Matityahu Fridkin

Denis Francois Hochstrasser

Carl R Merrill

Abraham Warshavsky

A chitosan composition which forms a hydrogel at near physiological pH and 37&#xb0; C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37&#xb0; C., that includes at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.

Injectable chitosan mixtures forming hydrogels

A chitosan composition which forms a hydrogel at near physiological pH and 37&#xb0; C., comprising at least one type of chitosan having a degree of acetylation in the range of from about 30% to about 60%, and at least one type of chitosan having a degree of deacetylation of at least about 70% is disclosed. Further disclosed is a chitosan composition which forms a hydrogel at near physiological pH and 37&#xb0; C., comprising at least one type of chitosan having a degree of deacetylation of at least about 70% and a molecular weight of from 10-4000 kDa, and at least one type of a chitosan having a molecular weight of from 200-20000 Da. Further disclosed are methods of preparation and uses of the chitosan compositions.

Amine-acryloyl and -methacryloyl derivatives and 1,6-heptadiene-4-ol can be used to provide crosslinked polyacrylamide gels which are useful in protein and nucleic acid separation and detection. The gels crosslinked with the compounds of the present invention exhibit much less background silver staining than previously known acrylamide gels.

Polyacrylamide gels with improved detection of protein

An automated apparatus for conducting a broad range of organic synthesis reactions includes a first column carring a polymeric support, a second column carrying a second polymer support, and conduits connecting the two columns and permitting the circulation of fluids therebetween. In operation each polymeric support carries a different reactive species and a liquid medium containing a specifically selected intermediate reactant, in a solvent, is circulated between the columns in order to remove the reactive species from the first support by reaction with the intermediate, and to permit the reactive species thus removed to react with the reactive second support, at the same time regenerating the original intermediate reactant. Sensors are placed at the entrance and exit of the second column carrying the second polymeric support. The sensors are capable of sensing the relative presence of the intermediate reactant. When the same content of intermediate reactant is sensed at both the entrance and exit of the second column, the computer causes the circulation to be automatically stopped as this indicates complete loading of the second column.

Apparatus for multipolymer synthesis of organic compounds

A broad range of organic synthesis reactions can be conducted by means of a process using two polymeric supports, each carrying different reactive species. A liquid medium containing a specifically selected intermediate reactant, in a solvent, is circulated between the supports in order to remove the reactive species from the first support by reaction with the intermediate, and permit the reactive species thus removed to react with the reactive species of the second support, at the same time regenerating the original intermediate reactant. This circulation continues until the second support is suitably loaded with the reaction product, at which time the circulation is stopped and the reaction products separated and recovered. The process may be carried out in an automated apparatus in which sensors are placed at the entrance and exit of the column carrying the second polymeric support. The sensors are capable of sensing the relative presence of the intermediate reactant. When the same content of intermediate reactant is sensed at both the entrance and exit of the second column, the circulation will be automatically stopped as this will indicate complete loading of the second column.

Method for multipolymer synthesis of organic compounds

Novel polyfunctional compounds and polymers are disclosed of the general formula ##STR1## wherein Q designates -X' or -X-.epsilon.-R; where X' designates ##STR2## where .alpha. is --OH, or --SH;

Metal complexing polymers

.alpha.-Substituted-3-(halomethyl)-4-hydroxybenzeneacetic acids, prepared by the halomethylation of .alpha.-substituted-4-hydroxybenzeneacetic acids are new and useful as starting materials for the preparation of cephalosporin and penicillin derivatives.

.alpha.-Substituted-3-(halomethyl)-4-hydroxybenzeneacetic acids

New 7-[4-hydroxy-3-(substituted methyl)phenyl]acetamido cephalosporin derivatives are prepared which are useful as antibiotics.

Cephalosporin derivatives

New 4-hydroxy-3-(substitutedmethyl)benzeneacetic acids have been prepared which are useful as starting materials in the preparation of cephalosporin and penicillin derivatives.

4-Hydroxy-3-(substitutedmethyl)-benzeneacetic acids

New indole derivatives of cephalosporin compounds have been prepared which are useful as antibiotics.

Indole cephalosporin derivatives

Novel cephalosporin compounds of the following formula are useful as antibiotic agents: ##STR1##

7-[(Sulfomethyl)phenyl]acetamidocephalosporin derivatives

7-2-Indolyl acetamido cephalosporin derivatives

New 7-[4-hydroxy-3-(substitutedmethyl)phenyl]acetamido penicillin derivatives are prepared which are useful as antibiotics.

Penicillin derivatives

Novel cephalosporin derivatives of the following formula are useful as antibacterial agents: ##STR1##

7-[(Substituted-isothioureamethyl)phenyl]-acetamidocephalosporin

New cephalosporin derivatives containing a formyl substituted pyrrole group and the processes for preparing same are described.

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Ness-Ziona, Israel

Abraham Patchornik