University of Illinois

Genalyte, Inc.

Abraham J Qavi

Matthew S Luchansky

Ryan C Bailey

Jared T Kindt

Lawrence Cary Gunn, Iii

Martin Anthony Gleeson

Adam L Washburn

Tate Owen

Ji-Yeon Byeon

Melinda S McClellan

Melinda S Mcclellan

Ryan C Balley

Lawrence C Gunn

Iii Gunn Lawrence C

Embodiments of the methods, compositions, and systems provided herein relate to enzymatic enhancement of immunoassays using photonic sensor arrays.

Methods and compositions for enhancing immunoassays

Various embodiments are drawn to systems and methods for detecting an analyte of interest in a sample including an optical sensor, a capture probe attached to a surface of the optical sensor wherein the capture probe is capable of binding to the analyte to form a duplex or complex, and an antibody capable of binding to the analyte, duplex, or complex. In several embodiments, systems and methods further include a particle attached to the antibody or capable of binding to the antibody. In several embodiments, systems and methods for analyte detection feature one or more of the following: high detection sensitivity and specificity, scalability and multiplex capacity, ability to analyze large analytes, and ability to detect or measure multiple individual binding events in real-time.

Optical analyte detection systems and methods of use

Growing community of inventors

Champaign, IL, United States of America

Abraham J Qavi