West Laboratories, Inc.

West Chemical Products, Incorporated

Abraham Cantor

Murray W Winicov

Edward A Nodiff

Murray A Winicov

A new group of compounds, generically classed as phenothiazinyl sulfides, are described having the formula: ##STR1## wherein n is 1 or 2, x and/or y and/or z represent 0, 1 or 2; R.sub.1 may be H, alkyl, aryl, alkaryl, acyl, haloacyl and biologically activating aminoalkyl groups known in the medicinal arts, such as --(CH.sub.2).sub.3 --N(CH.sub.3).sub.2, ##STR2## and -[2-(1-methyl-2-piperidyl)ethyl]; and R.sub.2 and/or R.sub.3 and/or R.sub.4 and/or R.sub.5 and/or R.sub.6 and/or R.sub.7 represent H, OH, Cl, Br, F, CF.sub.3, SH, NO.sub.2, CN, COOH, alkyl, alkoxy, sulfamoyl, dimethylsulfamoyl, dimethyl amino, aryl, alkaryl, acyl, aryloxy, methyl sulfonyl, methyl thio, and -S-phenothiazinyl substitutents; and as charge-transfer complexes of iodine therewith in which the number of moles of iodine associated with the molecule equals 1.5 (range 0.75 to 3.0) times the number of phenothiazinyl groups in the molecule. Methods for the preparation of the compounds are described. The phenothiazinyl sulfides appear to be active in the same industrial and biological applications as phenothiazine and its corresponding derivatives, and show distinctive activity in various uses and as charge-transfer complexes of novel electrochemical properties as illustrated, in-vitro, in combination with iodine as a cathode material.

Phenothiazinyl sulfides

An improved iodine tincture is provided by incorporating therein a small amount, preferably about 0.25 to 2.5 parts, per part by weight of iodine, of povidone, 1-vinyl-2-pyrrolidone polymer. In these proportions , the povidone modified tincture of iodine exhibits markedly reduced tendency to burn or sensitize skin areas on which it dries, is stable, and at the same time retains the essential germicidal activity of unmodified tincture of iodine. The new products can be formulated directly, or as concentrates yielding the improved tincture upon extension with a prescribed amount of aqueous-ethanolic diluent.

Stabilized iodine tincture

This invention relates to new and improved means for killing spores on instruments and the like utilizing the combination of glutaraldehyde and a detergent selected from the group consisting of nonionic, anionic and ampholytic surface active agents. The sporicidal kill activity of glutaraldehyde is enhanced by said detergents.

Killing bacterial spores with glutaraldehyde sporicidal compositions

This invention relates to new and improved means for killing spores on instruments and the like utilizing the combination of glutaraldehyde and a monoaldehyde, such as, for example, formaldehyde. The sporicidal kill activity of the composition is more rapid than previously possible, and more effective than the use of either glutaraldehyde or monoaldehyde alone.

Means for killing bacterial spores with glutaraldehyde sporicidal

The improved approach to the direct formulation of solid iodine carriers containing poly (N-vinyl-2-pyrrolidone) and an iodide, as disclosed in copending application Ser. No. 360,338, has been extended to the direct formulation of solid products containing, in addition to the PVP and iodide, compatible additives such as nonionic detergent, anionic detergent, elemental iodine and mixtures thereof, as well as to the direct formulation of other solid iodine carriers.

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Elkins Park, PA, United States of America

Abraham Cantor