Synthelabo

Abkar Vartanian

Guy Rossey

Alexander E Wick

Isaac Chekroun

Antonio Ugolini

Christian J Warolin

Francis Rose

Paul Fabiani

Process for the preparation of compounds of the general formula (I) ##STR1## wherein R is hydrogen or (C.sub.1-4)alkyl.

Process for the preparation of propionic acid derivatives

A process for the preparation of a methyl (+)-(2S,3S)-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)propionat e of the formula (I): ##STR1## in which X denotes hydrogen or chlorine, which process comprises reacting a 2-aminothiophenol of formula (II): ##STR2## in which X is as defined above, with methyl (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)propionate, in a 1,2-dichloroethane solvent.

Process for the preparation of methyl

2,3-Dihydro-imidazo[1,2-b]pyridazine derivatives of the formula: ##STR1## in which R.sub.1 represents a phenyl, halogenophenyl, trifluoromethylphenyl, C(.sub.1-4)-alkylphenyl, (C.sub.1-4)-alkoxyphenyl, hydroxyphenyl, nitrophenyl, aminophenyl, (C.sub.1-4)-alkylaminophenyl, di-(C.sub.1-4)-alkylaminophenyl, acetamidophenyl, thienyl, pyridyl, furyl or nitrofuryl radical, R.sub.2 represents a hydrogen atom or a (C.sub.1-4)-alkyl radical, and R.sub.3 represents a hydrogen atom or a (C.sub.1-4)-alkyl, phenyl, halogenophenyl, trifluoromethylphenyl, (C.sub.1-4)-alkylphenyl, (C.sub.1-4)-alkoxyphenyl, hydroxyphenyl, nitrophenyl, aminophenyl, (C.sub.1-4)-alkylaminophenyl, di-(C.sub.1-4)-alkylaminophenyl or acetamidophenyl radical, and its addition salts with pharmaceutically acceptable acids are useful in therapy as antidepressants. They may be made by cyclization of compounds of the formula: ##STR2##

2,3-Dihydro-imidazo[1,2-b]pyridazine derivatives, their preparation and

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Meulan, France

Abkar Vartanian