Genentech, Inc.

Xenon Pharmaceuticals Inc.

Abid Hasan

Christoph Martin Dehnhardt

Brian Salvatore Safina

Sultan Chowdhury

Shaoyi Sun

Alla Yurevna Zenova

Qi Jia

Thilo Focken

Michael Edward Grimwood

Ivan William Hemeon

Philippe Bergeron

Wei Gong

Michael Scott Wilson

Jean-Christophe Andrez

Paul Robert Bichler

Daniel P Sutherlin

Zhiguo Liu

Tao Wang

Daniel Fred Ortwine

Kwong Wah Lai

Kristen Nicole Burford

Jun M Li

Steven McKerrall

Jiuxiang Zhu

Andrew D White

Teresa Phuongtram Nguyen

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Therapeutic compounds and methods of use thereof

The invention provides a compound of formula: or a salt thereof, wherein the variables R, n, ring A, ring B, R, R, R, R, R, R, R, R, R, and Rhave the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The invention provides compounds having activity as sodium channel (e.g., NaV1.7) inhibitors that are useful for treating sodium channel-mediated diseases or conditions, such as pain, as well as other diseases and conditions associated with the mediation of sodium channels, and compositions containing such compounds and methods for using such compounds and compositions.

Substituted benzamides and methods of use thereof

The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables R, R, subscript n, subscript q, ring A, X, L, subscript m, X, R, R, R, R, R, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. 

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Burnaby, Canada

Abid Hasan