Council of Scientific and Industrial Research

Abid Hamid Dar

Ram Asrey Vishwakarma

Ajit Kumar Saxena

Anamika Khajuria

Asif Khurshid Qazi

Aashiq Hussain

Parduman Sharma

Ahmed Kamal

Sandip Bibishan Bharate

Dilip Manikrao Mondhe

Parvinder Pal Singh

Shreyans Kumar Jain

Amit Nargotra

Sanghapal Damodhar Sawant

Shashank Kumar Singh

Samdarshi Meena

Yellamelli Valli Venkata Srikanth

Varun Pratap Singh

Ramesh Mudududdla

Mohammed Naseer Ahmed Khan

Mohammed Ashraf

Bhushan Shashi

Gudasalamani Ravikanth

Ramesh Vasudeva

Kumara Patel Mohana

Kotiganahalli Narayanagowda Ganeshaiah

Tabasum Sidiq

Deepika Singh

Jai Prakash Sharma

Gousia Chashoo

Shaanker Ramanan Uma

Sundeep Jaglan

Anjaneya Aravind Kumar Kolluru

Nayan Chanauria

Sunil Kumar Bhola

Tabasum Sidi

Irum Sehar

Parduman Raj Sharma

The present invention relates to novel chromone alkaloid of formula 1 isolated from the plant. The compound 5,7-dihydroxy-6-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-one, is found to be a potential inhibitor of cell growth and proliferation and also inhibits production of pro-inflammatory cytokines. The formulations of this particular compound can be used for treatment of cancer and inflammation. 

Chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders

The present invention relates to a peptaibol having sequence AcAib-Asn-Aib-Leu-Aib-Pro-Aib-Asn-Leu-Pro-Ileuol, isolated from endophytic fungushaving accession number MTCC 5721. The peptaibol is named as brachiating D. The present also related to a process for isolating the peptaibol from and use of the peptaibol as a pharmacologically active compound as a strong immunosuppressants and as an anticancer agents.

Brachiatin D and process for production thereof

Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described (formula 1) together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention.

Boronic acid bearing liphagane compounds as inhibitors of P13K-&#x3b1; and/or &#x3b2;

The present invention provides compounds of general formula A useful as potential anticancer agents against human cancer cell lines and apoptosis inducers. The present invention further provides a process for the preparation of 2-anilino nicotinyl linked 2-amino benzothiazole conjugates of general formula (A), wherein R&#x2550;H or Cl; R&#x2550;H, OCHor F; R&#x2550;H, OCH, F or Cl; R&#x2550;H, OCHor F and X&#x2550;OCH, F or N0. 

2-anilino nicotinyl linked 2-amino benzothiazole conjugates and process for the preparation thereof

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Jammu, India

Abid Hamid Dar