Sun Pharmaceutical Industries Limited

Abhishek Tiwari

Rajamannar Thennati

Muthukumaran Natarajan

Nishith C Chaturvedi

Brijeshkumar Patel

Kunal Pandya

Ravishankara Madavati Nagaraja

Krunal Harishbhai Soni

Dhiren Rameshchandra Joshi

Vinod Sampatrao Burade

Rishit Mansukhlal Zalawadia

Pradeep Dinesh Shahi

Vipulkumar Shankarbhai Patel

The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.

GLP-1 analogues

Growing community of inventors

Gujarat, India

Abhishek Tiwari