Vyome Biosciences Pvt. Ltd.

Vyome Therapeutics Limited

Abhijit S Bapat

Shiladitya Sengupta

Sudhanand Prasad

Rajesh Sudhir Gokhale

Sumana Ghosh

Nilu Jain

Suresh Chawrai

Nidhi Arora

D Sreedhar Reddy

Mallika Mishra

Kirti Bajaj

Gauthami Mahesh

Sayali S Shah

Debabrata Mandal

The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA)-X-(L); (ii) [(AFA)-X]-L; (iii) AFA-[X-(L)]; or (iv) (AFA)-X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m' is 1 to 10; p is 1 to 10; n&#x2032; is 1 to 10; and q is 1 to 10, provided that q&#x2032; and n are not both 1; and m&#x2033; is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.

Conjugate-based antifungal and antibacterial prodrugs

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Delhi, India

Abhijit S Bapat