Merck Sharp + Dohme Corp.

Southern Research Institute

Abhijit Roychowdhury

F George Njoroge

John A Secrist, Iii

Subramaniam Ananthan

Joseph A Maddry

Robert C Reynolds

Cecil D Kwong

Hollis S Kezar, Iii

Neng-Yang Shih

John J Piwinski

Frank W Bennett

Ashok Arasappan

Feng Geng

Jeremy Clark

Anita T Fowler

Srikanth Venkatraman

Vinay M Girijavallabhan

Francisco Velazquez

Vishal Verma

Yuhua Huang

Joseph A Kozlowski

Ling Tong

Malcolm Maccoss

Bandarpalle B Shankar

Seong Heon Kim

Regina Huelgas

John A Secrist

Hollis S Kezar

John A Iii Secrist

Hollis S Iii Kezar

George F Njoroge

Iii Hollis S Kezar

Iii John A Secrist

The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R, X, Y, Z, R, R, R, R, R, R, R, R, R, Rand n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders. 

Substituted pyridine and pyrimidine derivatives and their use in treating viral infections

The present invention provides compounds of Formula (A): (Chemical formula should be inserted here as it appears on abstract in paper form) (A) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R, X, Y, Z, R, R, R, R, R, R, R, R, R, R, R, R, and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders. 

Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections

The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and pro-drugs of said compounds, wherein each of R, R, X, Y, Z, R, R, R, R, R, R, R, R, R, Rand n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.

Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections

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Birmingham, AL, United States of America

Abhijit Roychowdhury