Northeastern University

University of Florida Research Foundation, Incorporated

Abhijit Raghunath Kulkarni

Ganeshsingh Arjunsingh Thakur

Roger Lee Papke

Pushkar Mukund Kulkarni

Ritesh B Tichkule

Compounds are provided which bind to an allosteric site on the mammalian alpha-7 nicotinic acetylcholine receptor (alpha-7 nAChR) and act as positive allosteric modulators with or without allosteric agonist activity. The compounds are useful in diagnosing, preventing, or treating a variety of disorders involving cognition, learning, memory, neurodegeneration, drug addiction, inflammation, chronic pain, and neuropathic pain. The compounds also can be used to enhance memory and learning in normal individuals.

Ligands for alpha-7 nicotinic acetylcholine receptors and methods of treating neurological and inflammatory conditions

The present technology relates to compounds and compositions of Formulas I, II, VII, and VIII, and methods using such compounds. The compounds and compositions described herein may be used in the treatment or prophylaxis of addiction, metabolic syndrome, obesity, and/or a CB1 receptor-mediated disorder.

Growing community of inventors

Boston, MA, United States of America

Abhijit Raghunath Kulkarni