Concordia University

Dendritic Nanotechnologies, Inc.

Priostar Pty Ltd

Abhay Singh Chauhan

Armin Henry Gerhardt

Eric Andrew Newenhouse

Donald A Tomalia

Douglas R Swanson

Veera Reddy Pulgam

Cordell DeMattei

Baohua Huang

Joseph R Heinzelmann

Sonke Svenson

Michael A Zhuravel

Lori A Reyna

James David Owen

Cordell R Demattei

Rayan Terrell Hayes

Compositions and pharmaceutical compositions including a dendrimer-resveratrol complex and methods for making and using the compositions are described herein. Methods of treating cancer, cardiovascular disease, cardiac failure, diabetes, Alzheimer's disease, Parkinson's disease and other brain diseases, fatty liver disease, obesity, cataracts, osteoporosis, muscle wasting, sleep disorders, acoustic trauma, inflammatory disease, psoriasis, arthritis, colitis, aging, viral disease, reproductive disease, and skin conditions or disorders including administering a therapeutically effective amount of the compositions to a subject in need are also provided. The compositions may be topically applied to skin or mucous membranes.

Compositions comprising a dendrimer-resveratrol complex and methods for making and using the same

Compositions comprising a dendrimer-resveratrol complex making and using the same

Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.

Dendritic polymers with enhanced amplification and interior functionality

Growing community of inventors

Milwaukee, WI, United States of America

Abhay Singh Chauhan