Ohio State Innovation Foundation

Abhay R Satoskar

Eric M Bachelder

Alan Douglas Kinghorn

James Fuchs

Narasimham L Parinandi

Li Pan

Kristy Ainslie

Claudio M Lezama-Davila

Shalini Gautam

Kevin Peine

Disclosed herein are methods of using immunomodulatory sterols as vaccine adjuvants. Accordingly, certain embodiments relates to pharmaceutical compositions containing at least one antigen and at least one immunomodulatory sterol; and, methods of inducing an immunomodulatory response in a patient by administering an immunomodulatory-effective amount of at least one immunomodulatory sterol.

Sterols as novel immunomodulatory agents and their use as vaccine adjuvants

In one aspect, the invention relates methods and compositions for treating parasitic diseases, for example, leishmaniasis. In a further aspect, the compounds of the methods and compositions are isolated from. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Antileishmanial compositions and methods of use

Compositions and methods for inhibiting Leishmaniasis using AIs are provided. Aspects provide compositions and methods for administering AIs alone or in combination with other compounds to infected hosts.

Compositions and methods for inhibiting leishmania

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Upper Arlington, OH, United States of America

Abhay R Satoskar