Ipca Laboratories Limited

Piramal Enterprises Limited

Abhay Atmaram Upare

Ashok Kumar

Satish Rajanikant Soudagar

Manmohan Nimbalkar

Nalinakshya Balaram Panda

Sivaramakrishnan Hariharan

Rajesh Kumar Keshava Prasad Singh

Owen Chambers

Ashvini Kumar Nand Kishore Saxena

Damodharan Satagopan

Rajeshkumar Singh

The present invention provides a continuous process for the production of 1,2,2,2-tetrafluoroethyl difluoromethyl ether (desflurane) which comprises feeding continuously optimum molar quantities of 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether (CFCHClOCHF, Isoflurane) and anhydrous hydrogen fluoride, in a reactor in the vapor phase over a fluorination catalyst system comprising a metal pentahalide absorbed on a supporting substrate at a temperature ranging from 100&#xb0; C. to 180&#xb0; C., and separating 1,2,2,2-tetrafluoroethyl difluoromethyl ether (desflurane) continuously from the reactor. The process of the present invention enables continuous removal of desflurane product thereby minimizing co-production of byproducts and resulting in high conversion efficiency and yield of desflurane.

Process for production of 1,2,2,2-tetrafluoroethyl difluoromethyl ether (desflurane)

Improved processes using primary, secondary and tertiary alcohols and with safer mode of introduction of the reagent and reaction conditions are described. Further, the process of manufacture of Losartan potassium by use of alkali metal salt such as Potassium carbonate is disclosed. A process for preparation of the polymorphic Form I of Losartan potassium is also disclosed herein.

Process for the synthesis of Losartan potassium

A process for the synthesis of Losartan Potassium by reacting Trityl Losartan in a primary alcohol with potassium tertiary alkoxide.

Losartan potassium synthesis

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Mumbai, India

Abhay Atmaram Upare