Ceptaris Therapeutics, Inc.

New Millennium Pharmaceutical Research, Inc.

Yaupon Therapeutics Inc.

US Worldmeds LLC

Actelion Pharmaceuticals Ltd

Abeer M Al-Ghananeem

Peter Anthony Crooks

Robert Alonso

Mark A Pimley

Anwar A Hussain

Lewis W Dittert

George A Digenis

Patrick DeLuca

Ahmad Malkawi

Patrick Deluca

The present invention provides for methods of using tert-butyl alcohol (TBA) co-solvent systems in the formulation and production of a pharmaceutical agent with low solubility. The present invention also provides for pharmaceutical compositions made using the novel co-solvent system. In one embodiment, the invention provides for a method of making dantrolene sodium (DS) formulation for intravenous use (DS-IV). This instantaneous reconstitution of the DS-IV product constitutes a significant improvement in the pharmacotherapy of patients undergoing malignant hyperthermia during surgery.

Co-solvent compositions and methods for improved delivery of dantrolene therapeutic agents

A composition and method for treatment of cancer. The composition for treating a skin disorder, comprising: a Nitrogen Mustard or an HX salt of the Nitrogen Mustard, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier that does not include petrolatum or ethanol does not include petrolatum or ethanol. The method comprises topically applying the composition of a Nitrogen Mustard or a HX salt of the Nitrogen Mustard to the affected skin, wherein the Nitrogen Mustard or the HX salt of the Nitrogen Mustard is in a non-aqueous vehicle or carrier that does not include petrolatum or ethanol, wherein the non-aqueous vehicle or carrier does not include petrolatum or ethanol.

Stabilized compositions of volatile alkylating agents and methods of using thereof

This invention provides a method of rapidly and reliably delivering codeine, alone or in combination with other compounds, to the systemic circulation by administration via the nasal route to produce rapid onset of beneficial effects in the treatment of pain or cough. The present invention further provides pharmaceutical compositions comprising codeine, and/or pharmaceutically acceptable salts thereof in a variety of unique pharmaceutical dosage forms, with and without other analgesic and/or antitussive compounds.

Intranasal codeine for the rapid suppression of cough and rapid relief of pain

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Lexington, KY, United States of America

Abeer M Al-Ghananeem