Abed Alqader Ibrahim

Anthony Lee Dellinger

Terry Earl Brady

Lowell Hughes

Melinda K M Goddard

Christopher E Starr

Lori Bush

The sustenance of life is driven by recognition of and access to energy sources. This process has remained unchanged over billions of years, guiding cellular nutrition through molecular recognition, akin to the food pyramid. At the atomic or nanoscale, chemotaxis enables organisms to identify ingestible matter and is driven by their need for fuel, rather than from the sustenance itself. Chemotaxis, one of nature's most potent yet invisible organic forces, operates independently of molecular charge dynamics to locate and identify microscopic sustenance. Infectious organisms, such as pathogenic microbes and parasites, depend on chemotactic pathways to locate nutrition across all scales. This invention leverages this phenomenon by 'baiting' these pathways with nutritive matter that encapsulates biocidal agents that are harmless to humans but lethal to infectious organisms once ingested. These nutritive biocidal agents could be employed as topical, oral, injectable, or aerosolized formulations, as well as hydrogel or slow-release implants.

Pathogenic affinity pathway of infectious or parasitic organisms for nanogram and picogram dosimetry prophylaxis or cure

This invention proposes a multifunctional topical composition that integrates halogen-functionalized fullerenes (halo-fullerenes and halo-endofullerenes) and metallic nanoparticles (NPs) to provide comprehensive skin protection and sanitizing, cosmetic enhancement and in some embodiments, treatment for various conditions. Leveraging the atomic scale and physical characteristics of halogenated fullerenes for deeper tissue penetration, the composition can provide antioxidant, antimicrobial, and UV protective benefits to foster cellular integrity, proliferation, and differentiation as healthy tissue. The proposed formulation can penetrate the stratum corneum and diffuse into underlying skin layers due to atomic-scale NPs that can readily deliver active ingredients through the skin via the pores of sweat glands; the lipid matrix of the stratum corneum; and hair follicles, sebaceous glands, and pilosebaceous pores. This composition uses stable inorganic antibacterial agents with a robust safety profile. Furthermore, it can provide UV protection from harmful radiation. The formulation comprises active ingredients that are specific, safe, stable and effective—and can be produced economically, making it suitable for a broad range of skin protection, sanitizing, enhancement and therapeutic products that promote skin health and wellbeing.

Atomic scale topical composition with enhanced interstitial cellular uptake for increased moisturizing, fluidity, antioxidant and radiation protection, antimicrobial cleansing and therapeutics for optimal dermal integrity and homeostasis

The present invention introduces an ophthalmic solution containing halo-fullerenes. When the spherical fullerene carbon cages are functionalized with halogens, the resulting halo-fullerenes demonstrate sustained antimicrobial activity. Fullerenes are also characterized by unique electron properties that impart antioxidant capabilities as free radical scavengers. Nonetheless, far smaller than ocular tissue cells, halo-fullerenes are biocompatible—and capable of penetrating intricate barriers, like the cornea and conjunctiva, with potential to achieve greater efficacy and symptom relief in chronic dry eye than conventional treatments. With remarkable surface area, halo-fullerenes also allow customization and possess a unique molecular architecture for broader applications. This multifunctional solution thus imparts antimicrobial activity, antioxidative protection, molecular lubrication, and shielding from external irritants while penetrating dense ocular structures. Without the need for antibiotic additives or preservatives, the invention can offer an effective, safe option for dry eye treatment, prophylaxis in contact lens solutions, and post-surgical care.

Broad-spectrum antimicrobial, biocompatible and preservative-free functionalized fullerenes ophthalmic solution with reactive oxygen species scavenging and advanced targeting, penetration, and hydration

Growing community of inventors

Greensboro, NC, United States of America

Abed Alqader Ibrahim