Warsaw Orthopedic, Inc.

Proteapex Therapeutics, LLC

Abdulhafez A Selim

Lawrence A Shimp

Marina D'Angelo

Guobao Wei

Keyvan Behnam

Hsiu Ying Sherry Wang

The invention relates to the use of an active collagen matrix for culturing mammalian cells and the use of the active collagen matrix and cells for the treatment of disease.

Collagen matrix for cell therapy

The present invention provides compounds for disrupting the binding of a matrix metalloprotease (MMP) protein to a substrate protein at an interaction site other than the protease catalytic site. In particular the inventive compounds inhibit the MMP's ability to cleave a substrate protein. In some cases the compound may prevent activation of transforming growth factor beta (TGF&#x3b2;). The compounds are preferably polypeptide fragments of the hemopexin-like domain of the MMP, but may be mimetics thereof or peptides or mimetics of the portion of the MMP substrate protein to which the MMP interacts.

Compositions and methods for inhibition of MMP8:MMP8-substrate interactions

A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.

Compositions and methods for promoting bone formation

Compounds for inhibition of MMP13-substrate interactions and methods of use thereof to treat osteoarthritis and cartilage degeneration

Compositions and methods for inhibition of MMP13:MMP-substrate interactions

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Cordova, TN, United States of America

Abdulhafez A Selim