Orchid Chemicals & Pharmaceuticals Limited

Abdul Raheem Keeri

Sriram K Rajagopal

Virendra Kachhadia

Sridharan Rajagopal

Thanasekaran Ponpandian

Kamaraj Mani

Balaji Ramachandran

Punthalir Narayanaswamy

Umamaheswari Mani

Karnambaram Anandhan

Rajendran Praveen

Suresh Rathinasamy

Prabhu Daivasigamani

Praveen Rajendran

Provided herein are novel, stilbene like compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, metabolites, prodrugs, solvates, pharmaceutically acceptable salts and compositions thereof. These compounds can inhibit HDACs and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc. 

Histone deacetylase inhibitors

Novel compounds of the general formula (I), having histone deacetylase (HDAC) inhibiting enzymatic activity, their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel compounds of the general formula (I). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a novel compound of formula (I). 

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Kanpur, India

Abdul Raheem Keeri