Other

Hoechst Marion Roussel

Abdel Karim Braham

Didier Babin

Rene Zalisz

Pierre Smets

Khalid Islam

Stephen Hawser

Derivatives of 2-[3-phenyl-2-propenyl]-1,2,3,4-tetrahydro-isoquinoline compounds of the formula in all their possible stereoisomer forms as well as their mixtures ##STR1## wherein X is nitrogen or --CH.dbd., R1, R2, --R3, R4, R5, R6 are individually selected from the group consisting of a) hydrogen, halogen, alkyl, O-alkyl, ##STR2## alkenyl, O-alkenyl, ##STR3## alkynyl, O-alkynyl, ##STR4## of up to 8 carbons, optionally substituted by at least one halogen, n is an integer of 0, 1 or 2, b) --NO.sub.2, --NH.sub.2 or --C.tbd.N, R1, R2, R3, R4, R5 and R6 being able to form rings in pairs, as well and their non-toxic acid addition salts useful as fungicides.

Derivatives of 2-[3-phenyl-2-propenyl]-1,2,3,4-tetrahydro isoquinoline,

A sequence of anti-direction, anti-messenger RNA oligonucleotides of .alpha.-TNF characterized in that it possesses the structure of the formula ##STR1## wherein X is hydrogen, or a sequence of 1 to 17 oligonucleotides in free form, in alkylated form, in sulfurated form or in the form of a poly L-lysine derivative useful for stopping the production of .alpha.-TNF.

Oligonucleotides that inhibit production of .alpha.-tumor necrosis factor

Growing community of inventors

Saint Denis, France

Abdel Karim Braham