Centre National De La Recherche Scientifique

Institut Gustave Roussy

Université Paris-Saclay

Institut National De La Sante Et De La Recherche Medicale

Université Paris—sud

Institut National De La Sante Et De La Recherche Medicale (Inserm)

Universite Paris-Saclay Parc Technologique

Abdallah Hamze

Olivier Provot

Mouad Alami

Ilhem Khelifi

Jean-Daniel Brion

Jérôme Bignon

Sébastien Apcher

Romain Darrigrand

Mouâd Alami

Timothée Naret

Joanna Bakala

Samir Messaoudi

Joëlle Dubois

Jian-Miao Liu

Vincent Blanchard

Nada Makky-ibrahim

Jean-François Peyrat

Anne Giraud

The present invention relates to the Compound of following formula (I): or a pharmaceutically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing such a compound and a method for preparing such a compound.

Compounds with tubulin polymerisation inhibitory activity and immunomodulatory properties

Disclosed are compounds having the formula (I): wherein Rrepresents a group: —NH, —NHCOR, —NHCOOR, —(C-C)alkenylene-CO—NH—OH, —(C-C)alkynylene-CO—NH—OH or —OH; Rrepresents a group: —OCH, —OCHCH, —SCH, —SCHCHor —OCHF; Rrepresents a hydrogen atom or a group: —CH, —CN, —F, —Cl or —OR; Rrepresents a hydrogen atom or a group: —CH, —CN, —F, —Cl or —OR; Rrepresents a group: —(C-C)alkyl or —CF; Rrepresents a group: —(C-C)alkyl or —CF; Rrepresents a group: —(C-C)alkyl or —CF; and Rrepresents a group: —(C-C)alkyl or —CF; in the state of a base or acid or acid salts or base salts or in the form of hydrate or of solvate. Also disclosed are drug conjugates including such compounds.

Drug conjugate comprising quinoline derivatives

The present invention relates to the design of novel molecules, referred to as 'multi-target' molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDACs) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the 'multi-target' molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one &#x201c;multi-target&#x201d; molecule, and the use of such compositions in the treatment of cancer.

'Multi-target' compounds with inhibitory activity towards histone deacetylases and tubulin polymerisation, for use in the treatment of cancer

The invention relates to a compound of the formula (I) in which: R, Rand Rare independently a methoxy group optionally substituted by one or more fluorine atoms; Ris a hydrogen atom; Rand Rare identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.

Iso CA-4 and analogues thereof as potent cytotoxic agents inhibiting tubuline polymerization

Growing community of inventors

Massy, France

Abdallah Hamze