Council Of Scientific And Industrial Research

Aashiq Hussain

Ram Asrey Vishwakarma

Asif Khurshid Qazi

Sandip Bibishan Bharate

Ajit Kumar Saxena

Abid Hamid Dar

Parduman Sharma

Ajay Kumar

Sonali Sandip Bharate

Prashant Joshi

Anamika Khajuria

Dilip Manikrao Mondhe

Girish Badrinath Mahajan

Ashok Kumar

Shashi Bhushan

Parvinder Pal Singh

Shreyans Kumar Jain

Santosh Kumar Guru

Sanghapal Damodhar Sawant

Amit Nargotra

Samdarshi Meena

Suresh Kumar

Ramesh Mudududdla

Nayan Chanauria

Baljinder Singh

Abid Hamid

Zahoor Wani

Anjaneya Aravind Kumar Kolluru

Sunil Kumar Bhola

Tabasum Sidi

Shaanker Ramanan Uma

Gudasalamani Ravikanth

Ramesh Vasudeva

Kumara Patel Mohana

Kotiganahalli Narayanagowda Ganeshaiah

Tabasum Sidiq

Parduman Raj Sharma

The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease. 

10-substituted colchicinoids as potent anticancer agents

The present invention relates to novel chromone alkaloid of formula 1 isolated from the plant. The compound 5,7-dihydroxy-6-(3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4H-chromen-4-one, is found to be a potential inhibitor of cell growth and proliferation and also inhibits production of pro-inflammatory cytokines. The formulations of this particular compound can be used for treatment of cancer and inflammation. 

Chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders

Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described (formula 1) together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention.

Boronic acid bearing liphagane compounds as inhibitors of P13K-&#x3b1; and/or &#x3b2;

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Jammu, India

Aashiq Hussain