Massachusetts Institute of Technology

University of California

Sandia Corporation

Aarthi Chandrasekaran

Ram Sasisekharan

Karthik Viswanathan

Rahul Raman

Xiaoying Koh

David Arthur Berry

Anup Kumar Singh

Shiladitya Sengupta

Viswanathan Sasisekharan

S Raguram

Aravind Srinivasan

Nathan J Hillson

Kristine Holley

Rajiv Bharadwaj

Chieh Chang

Ganlin Zhao

This invention provides methods and compositions for assembling biological constructs (e.g., plasmids, transformed cells, etc.). In certain embodiments the methods involve encapsulating separate components of the biological construct each in a fluid droplet confined in a fluid channel; optionally mixing droplets from different fluid channels to form a sequenced order of droplets carrying different components of the biological construct in a channel or chamber; and optionally combining two or more droplets each containing different components of the biological construct to permit the components to react with each other in one or more reactions contributing to the assembly of the biological construct.

Microfluidic platform for synthetic biology applications

The present invention provides, among other things, methods, reagents, and systems for the treatment, detection, analysis, and/or characterization of influenza infections.

Influenza treatment and/or characterization, human-adapted HA polypeptides; vaccines

The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys. The present invention provides methods for identifying novel umbrella-topology glycan decoys.

Decoy influenza therapies

The invention relates to compositions and methods for the modulation of the permeability of the epithelial cell barrier complex. In particular, the invention provides compositions and methods for using polysaccharides, preferably glycosaminoglycans, and agents that modify cell surface glycosaminoglycans, preferably glycosaminoglycan-degrading enzymes to modulate intercellular junctions. The compositions and methods provided can be used to facilitate the delivery of biologically active molecules.

Methods and compositions related to the modulation of intercellular junctions

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San Jose, CA, United States of America

Aarthi Chandrasekaran