Roche Diagnostics Operations, Inc.

Hitachi High-tech Corporation

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Aart Pieter Van Doorn

Yuichiro Hashimoto

Andreas Leinenbach

Florian Schweinberger

Tibor Toth

Stefan Quint

Marc Kaminski

The present disclosure is related to an analytical system comprising a liquid chromatographic (LC) system comprising a plurality of fluidic streams alternately connectable to a common detector via a stream-selection valve connected to the detector via a valve-to-detector conduit. The analytical system further comprises a wash pump fluidically connected to the stream-selection valve and configured to connect to the valve-to-detector conduit between two consecutive fluidic streams in order to wash liquid from a previous fluidic stream out of the valve-to-detector conduit before liquid from a subsequent fluidic stream enters the valve-to-detector conduit. An analytical method comprising switching between the fluidic streams and washing in between is also disclosed.

Analytical system and method including switching between liquid chromatography fluidic streams

A liquid chromatographic (LC) system is herein disclosed, the LC system comprising at least one fluidic stream comprising at least one HPLC column, a downstream valve connected to the at least one fluidic stream and connectable to a detector via a valve-to-detector conduit, wherein the at least one fluidic stream is connectable to the valve-to-detector conduit via the downstream valve, and where the LC system further comprises a downstream pump fluidically connected to the downstream valve and connectable to the at least one fluidic stream via the downstream valve in order to backflush and thereby clean the at least one HPLC column. A respective automated LC method is herein also disclosed.

LC system and method with column backflushing

Growing community of inventors

Munich, Germany

Aart Pieter Van Doorn