Case Western Reserve University

Aaron Weinberg

Santosh Ghosh

Umut Atakan Gurkan

A method of detecting epithelial cancer is described that includes the steps of: (a) determining the level of beta defensin 3 (BD-3) and beta defensin 2 (BD-2) in a suspect sample obtained from a subject; (b) comparing the level of BD-3 to BD-2 determined in the suspect sample to obtain a suspect BD-3/BD-2 ratio, (c) comparing the suspect BD-3/BD-2 ratio to a healthy BD-3/BD-2 ratio to obtain a diagnostic BD-3/BD-2 ratio; and (d) characterizing the subject as having epithelial cancer if the diagnostic BD-3/BD-2 ratio is greater than 1. A microfluidic device for detecting epithelial cancer using the diagnostic BD-3/BD-2 ratio is also described.

Epithelial cancer evaluation using beta defensin

A method of detecting &#x3b2;-defensin in a bodily sample from a subject includes reducing the electrostatic interaction between &#x3b2;-defensin and negatively charged moieties in the bodily sample prior to detecting the &#x3b2;-defensin with an antibody or epitope binding fragment thereof.

Method of detecting human &#x3b2;-defensins

This application provides, in part, novel polypeptides and nucleic acids that affect induction of defensins, and methods of making and using same.

Defensin-inducing agents

The disclosure provides, among other things, beta-defensin related agents for the treatment and prevention of viral infections, and particularly HIV infections. The disclosure provides methods for identifying additional beta-defensin related agents and for improving available beta-defensin related agents.

Growing community of inventors

Shaker Heights, OH, United States of America

Aaron Weinberg