The Scripps Research Institute

Synthorx, Inc.

Omniome, Inc.

Pacific Biosciences of California, Inc.

Aaron W Feldman

Floyd E Romesberg

Vivian T Dien

Jerod Ptacin

Carolina E Caffaro

Yorke Zhang

Hans Aerni

Emil C Fischer

Denis A Malyshev

Michael P Ledbetter

Rebekah J Karadeema

Anne Xiaozhou Zhou

Lingjun Li

Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

Incorporation of unnatural nucleotides and methods thereof

Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more unnatural amino acids. Further provided are compositions, cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism.

Reagents and methods for replication, transcription, and translation in semi-synthetic organisms

Disclosed herein, inter alia, are methods for modifying a nucleotide, for example including reacting a nucleotide having a 3'-O-oxime moiety such as with a reagent having an &#x2014;ONHmoiety to produce a nucleotide having a 3&#x2032;-O&#x2014;NHmoiety such as wherein the reagent having the &#x2014;ONHmoiety further comprises alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, heteroalicyclyl, aralkyl, heteroaralkyl, or (heteroalicyclyl)alkyl.

Reversible modifications of nucleotides

Growing community of inventors

San Diego, CA, United States of America

Aaron W Feldman