Cornell Research Foundation Inc.

Aaron Sin

Michael L Shuler

Scott Meyers

Gregory T Baxter

Robert Andrew Harrison

Michael Simms Shuler

A cell culture device comprising a microscale chamber dimensioned to maintain a cell under conditions that give rise to a value for at least one pharmacokinetic parameter in vitro that is comparable to a value for the same at least one pharmacokinetic parameter obtained with respect to the same type of cell in vivo, wherein the microscale chamber is configured for flow of culture medium, and wherein the at least one pharmacokinetic parameter is selected from tissue size ratio, tissue to blood volume ratio, drug residence time, flow rate, circulatory transit time, liquid residence time, and liquid to cell ratio.

Devices and methods for pharmacokinetic-based cell culture system

A cell culture method using an in vitro microscale cell culture device having a first microscale chamber containing cells attached to an inner surface of the chamber and cell culture medium in contact with the cells. The cells are maintained in culture in the in vitro microscale cell culture device while flowing culture medium through the first chamber at a controlled rate to provide a liquid residence time value for the cells in the first chamber of the in vitro microscale cell culture device that is comparable to a liquid residence time value obtained with respect to comparable cells in vivo, such that metabolism by the cells in culture in the in vitro microscale cell culture device is comparable to metabolism by comparable cells in vivo.

Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.

A micropump has two chambers separated by an actuator for causing fluid to flow in the chambers. Each chamber is equipped with a ball that acts as a valve for allowing flow in a desired direction. The balls are heavier than the fluid being pumped, and reside at an interface between the chambers and passages feeding fluid into the chambers and provide a tight seal between the chambers and passages feeding the chambers when fluid pressure forces the fluid back toward the feeding passages.

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Ithaca, NY, United States of America

Aaron Sin