Dispensing Technologies B.v.

Wellstat Vaccines, LLC

Other

Aaron S Haleva

Wilhelmus Johannes Joseph Maas

Petrus Lambertus Wilhelmus Hurkmans

Francis Michon

Charles Quentin Davis

Paulo Nervo

Paolo Nervo

Samuel J Wohlstadter

Samuel L Moore

Dominicus Jan Van Wijk

Glen Otero

Peter Fusco

In exemplary embodiments of the present invention, Flair® based aerosol-type devices can be provided. Such, devices utilize a combination of Flair® technology, pre-compression valves and aerosol like pressurization of the dispensed liquid. Such a dispensing device has a main body comprising a pressure chamber, the latter being provided with a pressure piston and a pressure spring. The device further has a piston and a piston chamber which draws liquid from a reservoir and fills the pressure chamber with that liquid as a user operates the trigger in various compression and release strokes. The piston chamber has both an inlet valve and an outlet valve. In a dispensing head a valve is provided to regulate the strength of the flow and preclude leakage. Once the liquid is sufficiently pressurized, it can be dispensed by a user opening an activation valve, such as by pressing on an activation button, and spray can be abruptly stopped by a user ceasing to push on such button. Or, for example, in alternate embodiments without an activation button, once the liquid is sufficiently pressurized, continuous spray occurs until the pressure chamber is emptied. By repeatedly pumping the trigger before the pressure chamber is fully emptied, continuous spray can be achieved. By designing the input volume to be amply greater than the volume of the pressure chamber, continuous spray with fewer pumping strokes can be implemented.

Sprayer device with aerosol functionality—Flairosol

A preform can be made from two different materials that do not bond together by a bi-injection process, using the same mold. First an outer preform can be fashioned first, then an inner preform molded through a center hole in the outer preform, and the preforms connected. Inner/outer preform materials can be different, e.g., PET/polyolefin or polyamide, or the same, e.g., PET/PET. To prevent mutual bonding during molding of the second, a non-stick coating can be sprayed on a surface portion of the first preform prior to molding, the second. Manufacturing order can be either outer/inner, or inner/outer, and the non-stick coating sprayed on the inside/outside of the perform first molded.

Preforms for flair applications

Dispensing devices are provided. Such devices utilize a combination of Flair® technology, pre-compression valves and aerosol-like pressurization of the dispensed liquid. An example dispensing device has, for example, a main body comprising a pressure chamber, the latter being provided with a pressure piston and a pressure spring. The device further has a piston and a piston chamber which draws liquid from a container and fills the pressure chamber with that liquid as a user operates a trigger in various compression and release strokes. The piston chamber has both an inlet valve and an outlet valve. Liquid exiting the piston chamber under pressure enters a central vertical channel which is in fluid communication with both the pressure chamber and a dome valve, with pre-defined opening pressure, provided near the outlet channel at the top of the dispensing head.

Metered and active sprayer devices with aerosol functionality—Flairosol II

In exemplary embodiments of the present invention, various novel dispensing devices can be provided. Such devices can involve a range of sprayer heads and sprayer/foamer systems incorporating such heads. Novel sprayer/foamer heads can include buffers of various types. By using a buffer, a user need not continually be pumping the device in order for the device to be spraying or foaming. In exemplary embodiments of the present invention, such a buffer can be spring loaded, spring loaded combination, elastomeric or gas. In exemplary embodiments of the present invention, the buffer can be in line or adjacent to a piston chamber. If adjacent, it can be connected to the piston chamber with a one way valve, to provide for spray after a downstroke of the piston has been completed, or without, to allow spraying to cease once a user releases the trigger or other actuator. In exemplary embodiments of the present invention, such novel sprayers and foamers can be mounted upside down, in various 'Flairomop' devices, used to clean floors or the like. When using a buffer, a piston chamber can be designed to deliver greater amount of liquid per unit time than can be possibly dispensed through the nozzle or nozzles. The fraction of liquid that cannot be sent through the nozzle(s), due to their inherent restriction, can thus be sent to the buffer for dispensing after the piston downstroke has been completed. A volume of the piston chamber, a volume of the buffer, a pressure response of the buffer, the throughput of the nozzle, and the minimum opening pressure of the outlet valve can be arranged to restrict the outlet pressures of liquid droplets exiting the nozzle within a defined range.

Systems and methods to precisely control output pressure in buffered sprayers (DuO1)

In exemplary embodiments of the present invention, Flair&#xae; based aerosol-type devices can be provided. Such devices utilize a combination of Flair&#xae; technology, pre-compression valves and aerosol like pressurization of the dispensed liquid. Such a dispensing device has a main body comprising a pressure chamber, the latter being provided with a pressure piston and a pressure spring. The device further has a piston and a piston chamber which draws liquid from a reservoir and fills the pressure chamber with that liquid as a user operates the trigger in various compression and release strokes. The piston chamber has both an inlet valve and an outlet valve. In a dispensing head a valve is provided to regulate the strength of the flow and preclude leakage. Once the liquid is sufficiently pressurized, it can be dispensed by a user opening an activation valve, such as by pressing on an activation button, and spray can be abruptly stopped by a user ceasing to push on such button. Or, for example, in alternate embodiments without an activation button, once the liquid is sufficiently pressurized, continuous spray occurs until the pressure chamber is emptied. By repeatedly pumping the trigger before the pressure chamber is fully emptied, continuous spray can be achieved. By designing the input volume to be amply greater than the volume of the pressure chamber, continuous spray with fewer pumping strokes can be implemented.

Sprayer device with aerosol functionality&#x2014;flairosol

In exemplary embodiments of the present invention, 'Flairosol' dispensing devices can be provided. Such devices utilize a combination of Flair&#xae; technology, pre-compression valves and aerosol-like pressurization of the dispensed liquid. Such a dispensing device has, for example, a main body comprising a pressure chamber, the latter being provided with a pressure piston and a pressure spring. The device further has a piston and a piston chamber which draws liquid from a container, for example, the inner container of a Flair&#xae; bottle, and fills the pressure chamber with that liquid as a user operates a trigger in various compression and release strokes. The piston chamber has both an inlet valve and an outlet valve, which serve to prevent backflow. Liquid exiting the piston chamber under pressure (supplied by, a user pumping the trigger) enters a central vertical channel which is in fluid communication with both the pressure chamber (above the pressure piston) and a dome valve provided near the outlet channel at the top of the dispensing head. The dome valve has a preset pressure, such that once exceeded by the liquid, opens and allows for a spray. If the liquid pressure drops below such preset pressure, the dome valve closes off the outlet channel, which serves to regulate the strength of the flow and preclude leakage. Alternatively, in an activated embodiment, for example, once the liquid is sufficiently pressurized, it can be dispensed by a user allowing the dome valve to open by pressing on an activation button that removes a dome lock.

Metered and active sprayer devices with aerosol functionality ('Flairosol II')

In embodiments, aerosol-type devices are provided. The devices have a main body comprising a pressure chamber, with pressure piston and pressure spring, and a piston chamber which draws liquid from a reservoir and fills the pressure chamber as a user performs compression and release strokes. The piston chamber has both inlet and outlet valves. In a dispensing head a valve is provided to regulate the flow strength and preclude leakage. Once the liquid is sufficiently pressurized, it is dispensed by a user opening an activation valve, and spray can be abruptly stopped by closing the activation valve. In alternate embodiments, without an activation valve, once the liquid is pressurized, continuous spray occurs until the pressure chamber is fully emptied. Pumping the trigger before the pressure chamber is fully emptied achieves continuous spray. When the input volume is greater than the volume of the pressure chamber volume, continuous spray with fewer pumping strokes occurs.

Sprayer device with aerosol functionality&#x2014;Flairosol

Dispensing devices can include buffers. This obviates the need for continually pumping the device to dispense spray or foam. A buffer can be spring loaded, spring loaded combination, elastomeric or gas, and can be in line or adjacent to a piston chamber. Such sprayers and foamers can be mounted upside down. With a buffer, a piston chamber can deliver a greater amount of liquid per unit time than can be dispensed through the nozzle(s). The fraction of liquid that cannot be dispensed can be sent to the buffer for dispensing after the piston downstroke has completed. Volume of the piston chamber and buffer, pressure response of the buffer, throughput of the nozzle, and the minimum opening pressure of the outlet valve can be arranged to restrict the outlet pressures of liquid droplets exiting the nozzle within a defined range.

A system and method for assessing the immunological status of one or more individuals in a patient population is presented. The method includes establishing a database comprising a plurality of records of information each representative of the immune status of an individual in the population, each of said records including (1) current information from one or more assays for the presence of a biochemical, and (2) individual specific information comprising one or more of said individual's medical history, said individual's doctors' observations and historical, demographic, lifestyle, and familial information relating to said individual. The method further includes processing the information in said database to find trends or patterns relating to the immune status of individuals in said patient population; and using the said trends or patterns as part of a health care related decision making process.

Automated systems and methods for obtaining, storing, processing and utilizing immunologic information of an individual or population for various uses

A preform can be made from two different materials that do not bond together by a bi-injection process, using the same mold. First an outer preform can be fashioned, then an inner preform molded through a center hole in the bottom of the outer preform, and the preforms connected. Inner/outer preform materials can be different, e.g., PET/polyolefin or polyamide, or same, e.g., PET/PET. To prevent mutual bonding during molding of the second, a non-stick coating can be sprayed on a surface portion of the first preform prior to molding the second. Manufacturing order can be either outer/inner, or inner/outer, and the non-stick coating sprayed on the inside/outside of the preform first molded.

In exemplary embodiments of the present invention, 'Flairosol' dispensing devices can be provided. Such devices utilize a combination of Flair&#xae; technology, pre-compression valves and aerosol-like pressurization of the dispensed liquid. Such a dispensing device has, for example, a main body comprising a pressure chamber, the latter being provided with a pressure piston and a pressure spring. The device further has a piston and a piston chamber which draws liquid from a container, for example, the inner container of a Flair&#xae; bottle, and fills the pressure chamber with that liquid as a user operates a trigger in various compression and release strokes. The piston chamber has both an inlet valve and an outlet valve, which serve to prevent backflow. Liquid exiting the piston chamber under pressure (supplied by a user pumping the trigger) enters a central vertical channel which is in fluid communication with both the pressure chamber (above the pressure piston) and a dome valve provided near the outlet channel at the top of the dispensing head. The dome valve has a preset pressure, such that once exceeded by the liquid, opens and allows for a spray. If the liquid pressure drops below such preset pressure, the dome valve closes off the outlet channel, which serves to regulate the strength of the flow and preclude leakage. Alternatively, in an activated embodiment, for example, once the liquid is sufficiently pressurized, it can be dispensed by a user allowing the dome valve to open by pressing on an activation button that removes a dome lock.

Sprayer device with aerosol functionality ('Flairosol')

'Flairosol' dispensing devices are presented. They utilize a combination of Flair&#xae; technology, precompression valves and aerosol like pressurization of the dispensed liquid. An exemplary device has a main body comprising a pressure chamber, the latter being provided with a pressure piston and a pressure spring, a piston and a piston chamber which draws liquid from a container, and fills the pressure chamber with that liquid as a user operates a trigger in various compression and release strokes. The piston chamber has both an inlet valve and an outlet valve, which serve to prevent backflow. A dome valve can be provided near the outlet channel at the top of the dispensing head, such that once its pressure is exceeded by the liquid, it opens and allows for a spray. Alternatively, in an activated embodiment, the dome valve is locked unless opened by a user.

A liquid dispensing device is presented. The device has a main body and a dispensing head. The main body includes a pressure chamber, a pressure spring and a pressure piston, and the dispensing head includes a piston and a piston chamber, a channel in fluid communication with the pressure chamber, an inlet valve provided between said channel and said piston chamber, an outlet valve, an outlet channel, and an outlet valve lock.

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Oakhurst, NJ, United States of America

Aaron S Haleva