Los Alamos National Security, LLC

Triad National Security, LLC

Aaron S Anderson

Basil I Swanson

Jurgen G Schmidt

Pulak Nath

Harshini Mukundan

Andrew M Dattelbaum

Kiersten Danielle Lenz

A microfluidic device can include at least one separation unit defining a first chamber fluidly coupled to an opening and a trap chamber disposed downstream of the opening, and a second chamber that extends radially outwardly of the opening. The second chamber can be offset from the first chamber along a first axis of the device and along a second axis of the device. The separation unit can further comprise a membrane disposed between the first and second chambers and extending across the opening, the membrane being configured such that when a sample is received in the first chamber and the device is rotated, the sample flows across the membrane and filtrate passes through the membrane into the second reservoir and residue flows into the trap chamber.

Microfluidic device

The present invention provides a composite material including a substrate having an oxide surface, and, a continuous monolayer on the oxide surface, the monolayer including a silicon atom from a trifunctional alkyl/alkenyl/alkynyl silane group that attaches to the oxide surface, an alkyl/alkenyl/alkynyl portion of at least three carbon atoms, a polyalkylene glycol spacer group, and either a reactive site (e.g., a recognition ligand) or a site resistant to non-specific binding (e.g., a methoxy or the like) at the terminus of each modified SAM. The present invention further provides a sensor element, a sensor array and a method of sensing, each employing the composite material. Patterning is also provided together with backfilling to minimize non-specific binding.

Robust, self-assembled, biocompatible films

Growing community of inventors

Los Alamos, NM, United States of America

Aaron S Anderson