Cardiac Pacemakers, Inc.

Minnetronix, Inc.

Minnetronix Neuro, Inc.

Aaron R McCabe

Yi Zhang

Holly Elizabeth Rockweiler

Scott A Meyer

Yinghong Yu

Shibaji Shome

Carlos Alberto Ricci

Alok S Sathaye

Jeffrey E Stahmann

Krzysztof Z Siejko

Sunipa Saha

Imad Libbus

Paul Allan Haefner

Douglas R Daum

M Jason Brooke

Amy Jean Brisben

Emily Rolfes Meyering

Quan Ni

David J Yonce

Kevin John Stalsberg

Blake A Hedstrom

Abhi Vase

Kenneth N Hayes

Jiang Ding

Avram Scheiner

Anthony V Caparso

Yanting Dong

Marina V Brockway

Gary Thomas Seim

Geng Zhang

Jacob I Laughner

Jack M Mondry

Donald Lee Hopper

Clayton Scott Foster

David W Yost

Ben Krehbiel

Julie A Thompson

Keith L Herrmann

Elizabeth Scheurer

Jacob L Laughner

Allan Charles Shuros

Robert J Sweeney

James Kalgren

Dan Li

Deepa Mahajan

Derek Daniel Bohn

Eric Keith Enrooth

James A Esler

Rajesh Krishan Gandhi

Shivanand Lad

Lemont Baker

Chie Kawahara

Amrita Sawhney

Rachel A Taylor

Jilliann G Fricke

Pramodsingh Hirasingh Thakur

Jaeho Kim

John D Hatlestad

Kent Lee

Joseph M Pastore

Ronald W Heil, Jr

Yunlong Zhang

Shelley Marie Cazares

Richard O Kuenzler

Ron Heil

Bejan Michael Darbandi

John C Layton

Matt Stoll

Laura Marie Zitella Verbick

Mary Jane Rasmussen

Matthew Stoll

Donald I Hopper

Shivanand P Lad

Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. In an example, CSF is separated into a permeate and retentate using a tangential flow filter. The retentate is filtered again and then returned to the subject with the permeate. During operation of the system, various parameters may be modified, such as flow rate and waste rate.

Tangential flow filter system for the filtration of materials from biologic fluids

Systems, catheters, and methods for accessing and treating along the central nervous system are disclosed including sampling systems. An example sampling system may include a filter cassette designed to filter cerebrospinal fluid. The filter cassette may have an inlet region configured to be coupled to a catheter and configured to receive cerebrospinal fluid, one or more filters, and an outlet region configured to be coupled to an outlet of the catheter and to direct filtered cerebrospinal fluid to the catheter. A sampling port may be in fluid communication with the filter cassette. The sampling port may have a first end region configured to receive cerebrospinal fluid, a stopcock, a syringe port, and a second end region. The stopcock may be configured to shift between a first position where cerebrospinal fluid is directed from the first end region to the second end region and a second position where cerebrospinal fluid is directed from the first end region to the syringe port.

Systems, catheters, and methods for treating along the central nervous system

Systems and methods for treating biologic fluids are disclosed. Some disclosed embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject, heat CSF to a target temperature, cool CSF to a target temperature, apply light treatment to CSF, separate cells via their dielectric properties, apply spiral and/or centrifugal separation, introduce additives to target particles, and/or apply combinations thereof. The method may include the steps of withdrawing fluid comprising CSF, treating the fluid, and returning a portion of the treated fluid to the subject. During operation of the system, various parameters may be modified, such as flow rate.

Systems and methods for the conditioning of cerebrospinal fluid

An example of a system includes an implantable medical device (IMD) for implantation in a patient, where the IMD includes a cardiac pace generator, phrenic nerve stimulation (PS) sensor, a memory, and a controller, and where the controller is operably connected to the cardiac pace generator to generate cardiac paces. The controller is configured to provide a trigger for conducting a PS detection procedure and perform the PS detection procedure in response to the trigger. In performing the PS detection procedure the controller is configured to receive a signal from the sensor, detect PS using the signal from the sensor, and record the PS detection in storage within the IMD.

Ambulatory phrenic nerve stimulation detection

Disclosed embodiments include methods and devices for introducing a sheath into a human or animal subject. Some embodiments include a puncture tool that may simultaneously deliver a sheath and a needle to a desired anatomical location. The needle may be removed and the sheath may be used to define a space that may be used to conduct a procedure.

Introducer sheath and puncture tool for the introduction and placement of a catheter in tissue

Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. The method may include the steps of withdrawing fluid comprising CSF, filtering the volume into permeate and retentate by passing the fluid through a tangential flow filter, and returning the permeate to the subject. During operation of the system, various parameters may be modified, such as flow rate.

Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow

Cardiac anodal electrostimulation detection systems and methods are described, such as for distinguishing between cathodal-only capture and at least partially anodal capture (e.g., combined anodal and cathodal capture, or between two anodes of which only one captures nearby cardiac tissue, etc.).

Cardiac anodal electrostimulation detection

Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

Closed loop neural stimulation synchronized to cardiac cycles

An interactive representation of electrostimulation electrodes or vectors can be provided, such as for configuring combinations of electrostimulation electrodes. In an example, electrodes or test parameters can be presented graphically or in a table. A user interface can be configured to receive user-input designating electrode combinations or vectors for test or for use in programming an implantable or ambulatory medical device. The interface can be used to indicate suggested electrode combinations or vectors in response to a first selection of an electrode. Tests can be performed on electrode combinations and vectors, and the results of the tests can be presented to a user using the interactive representation. In an example, test results can be analyzed by a processor and optionally used to program an implantable or ambulatory medical device.

User interface system for use with multipolar pacing leads

An implantable cardiac device includes a sensor for sensing patient activity and detecting phrenic nerve activation. A first filter channel attenuates first frequencies of the sensor signal to produce a first filtered output. A second filter channel attenuates second frequencies of the accelerometer signal to produce a second filtered output. Patient activity is evaluated using the first filtered output and phrenic nerve activation caused by cardiac pacing is detected using the second filtered output.

Activity sensor processing for phrenic nerve activation detection

Growing community of inventors

Minneapolis, MN, United States of America

Aaron R McCabe