University of Colorado

Immunomolecular Therapeutics, Inc.

University of Florida Research Foundation, Incorporated

National Jewish Health

Aaron Michels

Peter Gottlieb

Steve Orndorff

Peter A Gottlieb

David A Ostrov

John W Kappler

Thomas J Anchordoquy

George S Eisenbarth

Maki Nakayama

Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to a autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.

Insulin mimotopes and methods of using the same

Compounds and compositions useful in methods of treating, ameliorating, or inhibiting the development of autoimmune diseases or Celiac disease by modulating the binding of DQ8 MHC class II molecules to antigenic peptides or fragments of antigenic peptides.

Compounds and methods for treating autoimmunity

Methods of administering methyldopa to a subject in a fasting state to increase bioavailability of the methyldopa.

Administration of oral methyldopa

Methods for inhibiting an autoimmune disease by administering to a subject a therapeutically effective amount of a composition that induces conversion of naive T cells into Foxp3+ regulatory T cells to induce immunosuppression in the subject. Methods for detecting in a subject an autoimmune disease or a predisposition to an autoimmune disease, and methods for assessing the efficacy of a therapy for an autoimmune disease, particularly type 1 diabetes.

Methods of treating, ameliorating, or inhibiting the development of autoimmune diseases by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease. The binding may be modulated by the administration of D-&#x3b1;-methyldopa, or pharmaceutical compositions comprising therapeutically effective amounts of D-&#x3b1;-methyldopa.

Methods of treating autoimmunity

The invention provides methods of preventing, treating or ameliorating autoimmune diseases, such as diabetes and celiac disease, by decreasing the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same.

Growing community of inventors

Aurora, CO, United States of America

Aaron Michels