Janssen Pharmaceutica Nv

Aaron M Kearney

Cheryl A Grice

Laurent Gomez

Adrienne M Landry-Bayle

Genesis M Bacani

Alejandro Santillán, Jr

Alice Lee-Dutra

James Patrick Edwards

Wendy Eccles

John J M Wiener

Christa C Chrovian

Virginia M Tanis

Scott D Bembenek

Taraneh Mirzadegan

Neelakandha S Mani

Brad M Savall

Kelly J McClure

Michael P Curtis

Frank Chavez

Kathleen C Sappey

Kia Sepassi

Eugene Y Cheung

Alvah T Wickboldt

Jing Liu

Xiaohu Deng

Anne Fourie

Susanne Lochner

Jimmy T Liang

Anne E Fitzgerald

Diego Broggini

Hartmut B Zinser

Matthew T Epperson

Alexandro Santillán, Jr

Kathleen C Sappy

Alejandro Santillan

Anne M Fourine

Anne M Fourie

John JM Wiener

Kelly J Mcclure

John J Wiener

John Wiener

Compounds with two fused bicyclic heteroaryl moieties and their pharmaceutical compositions, and methods of using them as leukotriene Ahydrolase (LTAH) modulators and for the treatment of diseases, disorders and conditions mediated by LTAH.

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Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene Ahydrolase (LTAH or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTAH activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.

Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.

Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase

Aryl-substituted bridged or fused diamines as modulators of leukotriene  A ydrolase

Benzofuro- and benzothienopyrimidine compounds are described, which are useful as Hreceptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by Hreceptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.

Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase

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Lakeside, CA, United States of America

Aaron M Kearney