I2 Pharmaceuticals, Inc.

Sea Lane Biotechnologies, LLC

Aaron L Kurtzman

Ramesh Bhatt

Lawrence C Horowitz

Charles H Hannum

Michael D Horowitz

Li Xu

Arun K Kashyap

Sihong Zhou

Ramesh R Bhatt

Ryann E O'Neil

Lawrence Horowitz

Michael Horowitz

Ryann E O' Neil

The present invention concerns the design and construction of diverse peptide and polypeptide libraries. In particular, the invention concerns methods of analytical database design for creating datasets using multiple relevant parameters as filters, and methods for generating sequence diversity by directed multisyntheses oligonucleotide synthesis. The present methods enable the reduction of large complex annotated databases to simpler datasets of related sequences, based upon relevant single or multiple key parameters that can be individually directly defined. The methods further enable the creation of diverse libraries based on this approach, using multisynthetic collections of discrete and degenerate oligonucleotides to capture the diverse collection of sequences, or portions thereof.

Construction of diverse synthetic peptide and polypeptide libraries

Embodiments concern constructs comprising surrogate light chain sequences. In particular, embodiments concern constructs that can bind to DR4 and/or DR5 and aspects relating to such constructs and their use.

Surrogate binding proteins which bind DR4 and/or DR5

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San Carlos, CA, United States of America

Aaron L Kurtzman