Illumina Corporation

Sonos, Inc.

Aaron Jones

David Louis Heiner

Michal Lebl

Brett M Ellman

Mark J Nibbe

Mark S Chee

Steven Mark Barnard

Daniele Giacobello

Saeed Bagheri Sereshki

Steve Fambro

Steven P Fambro

Steve R Burgett

Vit Pokorny

Systems and methods for audio processing include capturing first sound data via at least one microphone of a network microphone device (NMD) and determining, via a voice activity detection process, that the first sound data does not include voice activity. The first sound data is stored in a buffer, and the NMD forgoes spatial processing of the first sound data. The NMD can capture second sound data and determine, via the voice activity process, that the second sound data includes voice activity. The NMD spatially processes the sound data to produce filtered sound data. The NMD detects a wake word based on data in the buffer. After detecting the wake word, the NMD may determine an action to be performed based on the data in the buffer.

Systems and methods for power-efficient keyword detection

Systems and methods for audio processing include capturing sound data via at least one microphone of a network microphone device (NMD) and determining whether the captured sound includes voice activity. While in a first stage, the NMD forgoes spatial processing of the captured sound data. If the NMD determines that the detected sound includes voice activity, the NMD transitions to a second stage. In this second stage, the NMD spatially processes the detected sound to produce filtered sound data and detects a wake word. After detecting the wake word, the NMD may determine an action to be performed based on the captured sound data.

Disclosed herein are methods of method of making a substrate for performing a chemical synthesis reaction.

Methods of forming and using a solid-phase support

Described is a system and method for synthesizing polymeric molecules such as oligonucleotides and polypeptides. The system is capable of continuously synthesizing molecules by providing an array of reaction sites and an array of stations for carrying out synthetic manipulations. The reaction sites in the former array can be placed in a fixed order and at fixed intervals relative to each other. Similarly, the stations can be placed in a fixed order and at fixed intervals relative to each other. The two arrays can be moved relative to each other such that the stations carry out desired steps of a reaction scheme at each reaction site. The relative locations of the stations and the schedule for the relative movement can correlate with the order and duration of reaction steps in the reaction scheme such that once a reaction site has completed a cycle of interacting with the full array of stations then the reaction scheme is complete.

Continuous polymer synthesizer

An apparatus for high-throughput combinatorial synthesis of organic molecules including a reaction vessel for containing a combinatorial chemistry synthetic reaction, a liquid dispenser for dispensing the liquid, a liquid aspirator and an adjustment mechanism. The reaction vessel includes an ingress aperture allowing a liquid to enter into an interior of the vessel and an egress aperture for aspirating the liquid from the vessel. The liquid dispenser dispenses liquid through the ingress aperture. The liquid aspirator aspirates liquid through the egress aperture and includes a rotor for carrying the vessel and orbiting the vessel about an axis of rotation. The rotor is oriented generally in a horizontal plane and includes an adjustment mechanism for adjusting the angle of the vessel relative to the horizontal plane in response to the centrifugal force generated by orbiting the vessel about the axis or rotation. A method of combinatorial synthesis of organic molecules is also disclosed.

Oligonucleotide synthesizer

A method of forming a solid-phase support, the method including the steps of providing a substrate having a reaction vessel, dispensing a particle in the reaction vessel, and permanently bonding the particle in the substrate within the reaction vessel. The particle may include a microbead. The particle may include controlled pore glass. A method of synthesis is also disclosed that includes including the steps of providing a solid-phase support including a particle embedded to the substrate adjacent a surface of substrate, the particle being functionalized to covalently attach an intermediate compound of a synthetic reaction, dispensing a liquid including a reagent to the solid-phase support to effect the synthetic reaction, and removing the liquid from the solid-phase support by centrifugation, whereby the intermediate compound remains attached to the substrate by the particle.

Method of forming and using solid-phase support

The invention provides an apparatus and method for transferring a plurality of samples from an array of source sample locations to an array of destination sample locations. An apparatus or method of the invention are useful for reformatting samples in cases where the array of source sample locations differs in shape or orientation from the array of destination sample locations. The invention can be used to transfer fluid samples in the absence of an externally applied force. Because active automation is not required for transferring samples, the invention provides the advantage of a compact and efficient format for liquid handling.

Apparatus and methods for reformatting liquid samples

An apparatus for high-throughput combinatorial syntheses of organic molecules including a reaction vessel for containing a combinatorial-chemistry synthetic reaction, a liquid dispenser for dispensing the liquid, a liquid aspirator and an adjustment mechanism. The reaction vessel includes an ingress aperture allowing a liquid to enter into an interior of the vessel and an egress aperture for aspirating the liquid from the vessel. The liquid dispenser dispenses liquid through the ingress aperture. The liquid aspirator aspirates liquid through the egress aperture and includes a rotor for carrying the vessel and orbiting the vessel about an axis of rotation. The rotor is oriented generally in a horizontal plane and includes an adjustment mechanism for adjusting the angle of the vessel relative to the horizontal plane in response to the centrifugal force generated by orbiting the vessel about the axis of rotation. A method of combinatorial synthesis of organic molecules is also disclosed.

Growing community of inventors

San Diego, CA, United States of America

Aaron Jones