Other

Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Aaron H Leeman

Sherman Tim Waddell

Milana M Maletic

Gina M Santorelli

Dennis D Keith

Milton L Hammond

John F Finn

Michael Morytko

James M Balkovec

Xin Gu

Donald W Graham

Siya Ram

Susan D Aster

Jason J Hill

Triazole derivatives of structural formula I are selective inhibitors of the 11&#x3b2;-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome, and other symptoms associated with NIDDM.

Triazole derivatives as inhibitors of 11-&#x3b2; hydroxysteroid dehydrogenase-1

Sulfonyl derivatives of structural formula I are selective inhibitors of the 11&#x3b2;-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dyslipidemia, hyperlipidemia, hypertension, Metabolic Syndrome or Syndrome X, and other symptoms associated with NIDDM.

Sulfonyl compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1

Triazole derivatives as inhibitors of 11-&#x3b2;-hydroxysteroid dehydrogenase-1

Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1

Prolines as antimicrobial agents

Catechols as antimicrobial agents

Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of the general formula:

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Westfield, NJ, United States of America

Aaron H Leeman