Mirus Bio Corporation

Aaron G Loomis

Jon Asher Wolff

David B Rozema

James E Hagstrom

Sean D Monahan

David L Lewis

Vladimir S Trubetskoy

Hans Herweijer

Vladimir G Budker

Paul Michael Slattum

Lori Higgs

Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.

Compositions and processes using siRNA, amphipathic compounds and polycations

An ionic polymer is utilized in 'recharging' (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or negative charge such that the resulting complex has the desired net charge.

Charge reversal of polyion complexes

Growing community of inventors

Prairie du Sac, WI, United States of America

Aaron G Loomis