Surromed, Inc.

Ppd Biomarker Discovery Sciences, LLC

Other

Biogen Idec Ma Inc.

Caprion Proteomics Usa, LLC

Aaron B Kantor

James L Winkler

Ian Walton

Louis John Dietz

Scott M Norton

Byron Stephen Lee

Shalom Tsur

Chih-Hua Chung

Paul A Raju

Timothy L Wyant

Stefan Miltenyi

Jun Deng

J&uuml;rgen Schmitz

Susan Alters

Uwe Horchner

Karen L Cheal

Fawn Qian

Hua Lin

Susan Goelz

The amount of platelet surface proteins in a sample may be measured by collecting a sample containing platelets into a collection tube containing a platelet stabilizing composition, labeling the platelet surface protein and detecting by cytometry.

Method for monitoring resting and activated platelets in unfixed blood samples

The present invention provides an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of expression of biological markers in biological fluids. The system includes improved instrumentation for performing MLSC, and also includes improved particle detection and analysis methods. The system further comprises an informatics architecture for the analysis of data obtained from the MLSC in tandem with other medical information.

System for microvolume laser scanning cytometry

A system for laser scanning provides spectral flexibility needed for the spectroscopic monitoring of highly multiplexed samples, such as cellular and particle assays in whole blood or other suspensions. In accordance with embodiments of the present invention, the system comprises a scanner to direct an excitation laser through a sample, an objective to collect light emitted by the sample in response to the excitation laser, a spectrograph to disperse the emitted light over a plurality of wavelengths as a spectrum, and a charge coupled device for detecting the spectrum. The system can be used with samples having a variety of reporter tags, including one or more SERS tags, fluorescent organic and protein tags, and quantum dot tags. A laser scanning apparatus and method of using the same is also provided.

Polychronic laser scanning system and method of use

Novel biological markers indicative of the action of an anti-inflammatory or immunosuppressive drug can be used to evaluate drug efficacy and compare local and systemic drug effects. They can also aid in comparison of different drugs, doses, and delivery routes. The biological markers include cell populations, cell surface antigen expression levels, and soluble factor concentrations. Measurement values of the novel biomarkers were shown to change significantly in allergic, atopic asthmatic, and healthy subjects after administration of prednisone.

Biological markers for evaluating therapeutic treatment of inflammatory and autoimmune disorders

Tumor cells, particularly carcinoma cells, are separated from peripheral blood by magnetic sorting. The tumor cells are magnetically labeled with antibodies directed to tissue specific antigens, preferably cytoplasmic proteins. Labeling for cytoplasmic antigens is accomplished first permeabilizing, then fixing the cells. The cells are separated on a magnetic matrix. The number of tumor cells in the enriched fraction is used to calculate the number of tumor cells present in a patient hematopoietic sample.

Efficient enrichment and detection of disseminated tumor cells

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San Carlos, CA, United States of America

Aaron B Kantor