Greenmark Biomedical Inc.

Aareet Krsna Ganesh Shermon

Juewen Liu

Steven Bloembergen

Ian J McLennan

Abdel Elsayed

Nathan Jones

Ryan Wagner

Abdel Rahman Elsayed

A delivery device for an active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders. The nanoparticles may be made by applying a high shear force in the presence of a crosslinker. The particles may be predominantly in the range of 50-150 nm and form a colloidal dispersion of crosslinked hydrogel particles in water. The biopolymer may be functionalized. The aptamer may be conjugated directly to the cross-linked biopolymers. The active agent may be a drug useful for the treatment of cancer. The delivery device survives for a period of time in the body sufficient to allow for the sustained release of a drug and for the transportation and uptake of the conjugate into targeted cells. However, the biopolymer is biocompatible and resorbable.

Aptamer bioconjugate drug delivery device

Growing community of inventors

Waterloo, Canada

Aareet Krsna Ganesh Shermon