St. Jude Children's Research Hospital

A Thomas Look

Stephan W Morris

The present invention is based on the identification and sequence determination of a novel gene, ALK, which is fused to the gene encoding nucleophosmin (NPM) in translocations present in t(2;5) lymphoma cells. Based on homologies to other proteins, the amino acid sequence of the polypeptide encoded by the ALK (Anaplastic Lymphoma Kinase) gene is a membrane-spanning protein tyrosine kinase (PTK)/receptor. Antibodies to the ALK PTK/receptor and methods utilizing such antibodies are described, as are methods of using the ALK gene to isolate ligands for the ALK PTK/receptor.

Antibodies for recognition of alk protein tyrosine/kinase receptor

Kits for detecting chromosomal rearrangements

Method of detecting a chromosomal rearrangement involving a breakpoint in the ALK or NPM gene

Human ALK protein tyrosine kinase

The present invention is based on the identification and sequence determination of fusion proteins generated by translocation which is present in t(2:5) lymphoma cells. Using either the amino acid or nucleic acid sequences of the fusion proteins disclosed herein, the present invention provides methods of detecting and treating t(2;5) lymphoma.

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Boston, MA, United States of America

A Thomas Look