Merrell Pharmaceuticals, Inc.

Merrell Dow Pharmaceuticals

Monsanto Company

A Stanley Tyms

Alan D Cardin

Debra L Taylor

Raymond A Dwek

Thomas William Rademacher

Gary S Jacob

Sai P Sunkara

Paul S Liu

Combinations of retroviral inhibitors

Sulfonic acid stilbenes block the infection of cells by HIV and these compounds can be used to prevent viral infection.

Sulfonic stilbene compounds in the treatment of viral diseases

Sulfonic acid stilbenes block the infection of cells by HSV and CMV and these compounds can be used to treat viral infection.

Sulfonic stilbene derivatives in the treatment of viral diseases

Sulfonic acid stilbenes block the infection of cells by HSV, and CMV and these compounds can be used to treat viral infection.

Sulfonic stilbene derivatives in the treatment of viral disease

Certain Castanospermine ester derivatives of the formula: ##STR1## wherein R, R.sub.1 and R.sub.2 are each independently hydrogen, C.sub.1-14 alkanoyl, C.sub.1-14 alkenoyl, cyclohexanecarbonyl, C.sub.1-8 alkoxyacetyl, ##STR2## naphthalenecarbonyl optionally substituted by methyl or halogen; phenyl (C.sub.2-6 alkanoyl) wherein the phenyl is optionally substituted by methyl or halogen; cinnamoyl; pyridinecarbonyl optionally substituted by methyl or halogen; dihydropyridine carbonyl optionally substituted by C.sub.1 -C.sub.10 alkyl; thiophenecarbonyl optionally substituted by methyl or halogen; or furancarbonyl optionally substituted by methyl or halogen; Y is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen, trifluoromethyl, C.sub.1-4 alkylsulfonyl, C.sub.1-4 alkylmercapto, cyano or dimethylamino; Y' is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, halogen or it is combined with Y to give 3,4-methylenedioxy; Y' is hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or halogen; with R, R.sub.1 and R.sub.2 being selected in such a way that at least one of them, but not more than two of them, is hydrogen; are disclosed to be effective in treating diseases caused by Herpes Simplex Virus (HSV) Types 1 and 2.

Anti-herpes castanospermine esters

A method is disclosed for the treatment of herpesvirus infections comprising treating the infected host with an effective amount of an N-alkyl derivative of deoxynojirimycin in which the alkyl group contains from one to about six carbon atoms, and preferably is butyl.

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London, United Kingdom

A Stanley Tyms