Microdose Therapeutx, Inc.

Epix Delaware, Inc.

A Sekar Reddy

Sharon Shacham

Oren Becker

Yael Marantz

Dilara McCauley

Vincent Jacques

Ashis K Saha

Zhaoda Zhang

Pini Orbach

Efrat Ben-Zeev

Michael Xie

Srinivasa Rao Cheruku

Venkitasamy Kesavan

Dale S Dhanoa

Silvia Noiman

Dongli Chen

Boaz Inbal

Anurag Sharadendu

Shay Bar-Haim

Alexander Heifetz

Rosa Melendez

Dilara Mccaulay

Provided are adenosine analog compounds such as that act as P2Y receptors, e.g., the P2Yreceptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer.

Adenosine analogs and their use

Provided are adenosine analog compounds of the general formula that act as P2Y receptors, e.g., the P2Yreceptor, including pharmaceutical compositions; and uses thereof to treat or prevent diseases associated with that receptor, e.g., disorders relating to mucus secretion, such as cystic fibrosis, chronic obstructive pulmonary disorder (COPD), asthma, constipation, chronic idiopathic constipation, dry mouth (xerostomia), gum disease, and gastrointestinal problems caused by radiation and chemotherapy for cancer. 

The invention relates to 5-HT receptor modulators, particularly 5-HTantagonists. Novel piperidinylamino-thieno[2,3-d]pyrimidine compounds represented by Formula I, II and III, and uses thereof for treating conditions including pulmonary arterial hypertension, congestive heart failure, and hypertension.

Piperidinylamino-thieno[2,3-D] pyrimidine compounds

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Burlington, MA, United States of America

A Sekar Reddy