University of California

Other

New Zealand Agricultural Research Institute Limited

A Richard Chamberlin

James Bradley Aggen

Mark S Stanley

Carl W Cotman

Neale R Towers

Kathryn M Ross

Daniel R Dietrich

Werner Fischer

Richard J Bridges

Ian Garthwaite

Christopher O Miles

The present invention relates to a protienaceous compound or functionally active derivative or part thereof having a binding site for a group represented by formula (I) which is part of a group of toxins derived from various cyanobacteria, to a method for its production, to diagnostic kits and to an affinty matrix (e.g. for use in immunoaffinity columns, online detection and purifications devices) containing the proteinaceous compound as well as to methods for substantially decreasing the amount of a compound containing the group represented by formula (I) in fluids or for concentrating compounds, e.g. toxins, containing the group represented by formula (I) from fluids such as crude water samples, extracts of algae or other tissue samples, e.g. to determine toxin concentrations.

Congener independent detection of microcystin and nodularin congeners

A method of inhibiting the transport of a neurotransmitter away from the synapse comprising contacting a neurotransmitter transporter with a compound having the structure ##STR1## wherein ##STR2## or CONHR.sup.3 in any combination and and wherein R.sup.2 =OR.sup.3, NR.sup.3.sub.2, alkyl, or substituted alkyl and R.sup.3 =alkyl or substituted alkyl.

Method of inhibiting the transport of L-glutamate to treat CNS disorders

Growing community of inventors

Irvine, CA, United States of America

A Richard Chamberlin