Kaohsiung Medical University

A-Mei Huang

Chun-Nan Lin

Shyh-Chyun Yang

Tzyh-Chyuan Hour

Yeong-Shiau Pu

Jan-Gowth Chang

Chung-Yi Chen

Huang-Yao Tu

Bai-Luh Wei

Pei-Jung Lien

Shen-Jeu Won

Kim-Hong Gan

Kai-Wei Lin

Jih-Heng Li

Chiung-Hui Liu

Several ursolic acid derivatives and pharmaceutical compositions thereof are provided. The ursolic acid derivatives and the pharmaceutical compositions thereof have at least one of an anticancer and an anti-inflammatory effects. A method for increasing a reactive oxygen species in a cell is also provided. The method comprises a step of providing the cell with a pharmaceutical composition including an ursolic acid derivative.

Ursolic acid derivative and pharmaceutical composition thereof

The present invention is correlated with a derivative of 18&#x3b2;-glycyrrhetinic acid apt to suppressing cancer cells, which is selected from a group comprising of structure I and structure II: wherein residue Ris selected from one of CHand CHCH, residue Ris selected from one of COOCH, COOCHCH, COOCH(CH), CONHCHCH, CONHCHCHCH, and CONHCH(CH), and residue Ris selected from one of COOCHCH, COOCH(CH), CONHCHCH, CONHCHCHCH, and CONHCH(CH).

Derivative of 18&#x3b2;-glycyrrhetinic acid apt to suppress cancer cells

What is disclosed in the invention is a preparation method of a supercriticalextract, which is made from the material, the dried stem of. The extract is obtained by extractingwhich is pulverized as particles with supercritical carbon dioxide fluid. Theextract or its active ingredient, subamolide A, can be used to inhibit the growth of human urothelial carcinoma cell lines. In addition, theextract (or subamolide A) is able to synergistically inhibit the growth of human urothelial carcinoma cell lines with cisplatin (CDDP) or gemcitabine (Gem). Therefore, theextract (or subamolide A) can be an anticancer drug alone, or forms a pharmaceutical composition with CDDP (or Gem) to treat with cancers in respect of urinary system.

[object Object]

Growing community of inventors

Kaohsiung, Taiwan

A-Mei Huang