The General Hospital Corporation

A Gregory Sorensen

Bruce R Rosen

Elfar Adalsteinsson

Divya S Bolar

Lee H Schwamm

A system and method for accurately producing MR images of selected vascular compartments includes employing a control scan and a tag scan, each including velocity selective modules that suppress signal from blood flowing faster than a given cutoff velocity, to acquire control and tag sets of NMR data that may be subtracted to produce a compartment-specific MR image that is substantially free of information from stationary tissues and blood outside the selective vascular compartments. Accordingly, physiological parameters, such as oxygen saturation (SaO), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO), can be generated from the compartment-specific images. Further still, kinetic curves of oxygen exchange can be created, thus providing detailed insight into oxygen exchange dynamics.

System and method to analyze blood parameters using magnetic resonance imaging

A bolus containing optical and MRI contrast agents is administered to a patient for determining quantitative perfusion indices from perfusion weighted magnetic resonance imaging analysis (PWI). The optical contrast agent time-concentration data, which can be obtained non-invasively, is used to define an arterial input function. The MRI contrast agent time concentration can be non-invasively determined using MRI to define a tissue function. An MRI time-signal curve can be determined by deconvolving the arterial and tissue functions. In one embodiment, SVD is used to determine a residue function from which a flow map can be computed.

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Belmont, MA, United States of America

A Gregory Sorensen