University of California

A Geoffrey Skillman

Irwin D Kuntz

Jonathan A Ellman

Christina E Lee

Gary S Lynch

Ching C Wang

Xiaoning Bi

Connie M Oshiro

Diana C Roe

Ellen K Kick

Guangcheng Liu

John Somoza

Tasir Haque

Jon P Page

Ronaldus Marcellus Knegtel

The present invention relates to () non-peptide aspartyl protease inhibitors; (ii) methods for modulating the processing of an amyloid precursor protein (APP); (iii) methods for modulating the processing of a tau protein (&#x3c4;-protein); and (iv) methods for treating neurodegenerative diseases. For instance, in one embodiment, the present invention provides a method for modulating the processing of an amyloid precursor protein (APP), the method comprising contacting a composition containing the APP with an aspartyl protease inhibitor having the formula: wherein: RRand Rare members independently selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, aryloxyalkyl, substituted aryloxyalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heterocycles, substituted heterocycles, heterocyclicalkyl and substituted heterocyclicalkyl; and Rand Rare independently selected from the group consisting of hydrogen, halogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, aryloxyalkyl and substituted aryloxyalkyl; or Rand Rand the carbons to which they are bound join to form an optionally substituted carbocyclic or heterocyclic fused ring system having a total of 9- or 10-ring atoms within the fused ring system.

Methods for treating neurodegenerative disorders using aspartyl protease inhibitors

The present invention provides non-peptide cathepsin D binding compounds and methods for using such compounds in the detection, labelling and inhibition of cathepsin D.

Nanomolar, non-peptide inhibitors of cathepsin D

The use of certain heterocyclic derivatives for treating parasitic protozoa infections in mammals, in particular bovine trichomoniasis and giardiasis, is disclosed.

Heterocyclic derivatives as inhibitors of purine salvage

Growing community of inventors

San Francisco, CA, United States of America

A Geoffrey Skillman