Masatoshi Maeki

Title: Masatoshi Maeki: Innovator in Lipid Nanoparticle Technology

Introduction

Masatoshi Maeki is a prominent inventor based in Sapporo, Japan. He has made significant contributions to the field of lipid nanoparticle technology, particularly in the context of genome editing and drug delivery systems. With a total of 2 patents, his work is paving the way for advancements in medical applications.

Latest Patents

One of Maeki's latest patents focuses on a lipid nanoparticle designed to encapsulate nucleic acids required for genome editing. This invention addresses the challenge of achieving high genome editing efficiency through a novel alcohol dilution method using flow channels. The lipid nanoparticle comprises a lipid component, a DNA nuclease, a guide RNA, and a single-stranded oligonucleotide. The specific ratios of the lipid components are crucial for the functionality of the nanoparticle, with the pH-sensitive cationic lipid making up 30-50 mol %, the neutral phospholipid 20-50 mol %, and the polyalkylene glycol-modified lipid 1-4 mol %.

Another significant patent involves a flow channel structure that facilitates the controlled production of lipid particles or micelles. This structure is designed to enhance the precision of particle size in nano-sized carriers, which are essential for effective drug delivery systems. The flow channel features a two-dimensional design with multiple structural elements, allowing for improved control during the formation of lipid particles.

Career Highlights

Masatoshi Maeki is affiliated with Hokkaido University, where he conducts his research and development in lipid nanoparticle technology. His innovative work has garnered attention in the scientific community, contributing to advancements in both genome editing and drug delivery methodologies.

Collaborations

Maeki collaborates with notable colleagues, including Manabu Tokeshi and Yusuke Sato. Their combined expertise enhances the research efforts in lipid nanoparticle technology and its applications.

Conclusion

Masatoshi Maeki's contributions to lipid nanoparticle technology are significant and impactful. His innovative patents are set to advance the fields of genome editing and drug delivery, showcasing the importance of his work in modern science.